CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Development of an in vitro co-culture system to assess the DILI-related potential of drugs
DOI 10.1055/s-0033-1360854
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Autor:innenF Rohr, C Hempt, A Luch, S Zellmer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Drug-induced liver injury (DILI) is the main reason for the withdrawal of drugs from the pharmaceutical market due to unpredictable severe toxic side effects. DILI can not be sufficiently explained by the direct toxicity of a drug on hepatocytes but it also involves the interaction of hepatocytes with non-parenchymal cells (NPC). For the study of the effects of xenobiotics on liver metabolism, the co-c…
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Zitierempfehlung
F Rohr, C Hempt, A Luch, S Zellmer (2014) Development of an in vitro co-culture system to assess the DILI-related potential of drugs. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360854
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