CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Development of shRNA transgenic mice for preclinical studies of the MKK4 regeneration kinase
DOI 10.1055/s-0033-1360855
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Autor:innenT Wuestefeld, M Pesic, TW Kang, NP Malek, PK Premsrirut, SW Lowe, L Zender
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The liver harbors a distinct capacity for endogenous regeneration; however, liver regeneration is often impaired in disease and therefore insufficient to compensate for the loss of hepatocytes and organ function. We recently identified MKK4 as a key regulator of liver regeneration by an in vivo RNAi screen. We could show that the knock down of MKK4 in hepatocytes increases their regenerative capacity and robustness.…
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Zitierempfehlung
T Wuestefeld, M Pesic, TW Kang, NP Malek, PK Premsrirut, SW Lowe, L Zender (2014) Development of shRNA transgenic mice for preclinical studies of the MKK4 regeneration kinase. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360855
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