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Hepatic stellate cell specific endoglin deletion modulates TGF-β signaling and aggravates liver fibrosis in two experimental models of murine liver injury
DOI 10.1055/s-0033-1360866
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Autor:innenM Alsamman, V Sterzer, S Meurer, H Sahin, R Weiskirchen, C Trautwein, D Scholten
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Hepatic stellate cells (HSC) are the major source for extracellular matrix (ECM) production in liver fibrosis. Endoglin (ENG) is a type III auxiliary receptor for TGF-β that is expressed on HSCs. Due to different splicing there are two ENG isoforms, L- and S-Endoglin, which modulate TGF-β signaling differentially. TGF-β is the a profibrotic cytokine expressed in response to liver injury. This study analy…
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Zitierempfehlung
M Alsamman, V Sterzer, S Meurer, H Sahin, R Weiskirchen, C Trautwein, D Scholten (2014) Hepatic stellate cell specific endoglin deletion modulates TGF-β signaling and aggravates liver fibrosis in two experimental models of murine liver injury. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360866
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