CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Human keratin 8 variants predispose to acetaminophen hepatotoxicity
DOI 10.1055/s-0033-1360899
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Guldiken, Q Zhou, O Kucukoglu, M Rehm, LP James, C Trautwein, MB Omary, P Strnad
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Keratins 8 and 18 (K8/K18) are the intermediate filaments of digestive epithelia and display an important hepatoprotective function. Accordingly, K8/K18 variants predispose humans to chronic liver disease and to acetaminophen toxicity. Given that K8 G62C and K8 R341 H/C are abundant K8 variants in European population, we studied their importance using newly generated/previously described mice subjected to acetaminop…
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Zitierempfehlung
N Guldiken, Q Zhou, O Kucukoglu, M Rehm, LP James, C Trautwein, MB Omary, P Strnad (2014) Human keratin 8 variants predispose to acetaminophen hepatotoxicity. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360899
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