CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Tauroursodeoxycholic acid exerts anti-apoptotic effects by a MKP-1- and PKA-dependent mechanism in rat liver
DOI 10.1055/s-0033-1360945
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Autor:innenA Sommerfeld, R Reinehr, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Ursodeoxycholic acid, which in vivo is converted to its taurine conjugate tauroursodeoxycholic acid (TUDC), is a mainstay for the treatment of cholestatic liver disease. TUDC is also effective in protecting hepatocytes for apoptosis induced by hydrophobic bile salts. The aim of the study was to elucidate the underlying signaling events. Methods: Rat livers were perfused with GCDC (20µmol/L) and TUDC (2…
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Zitierempfehlung
A Sommerfeld, R Reinehr, D Häussinger (2014) Tauroursodeoxycholic acid exerts anti-apoptotic effects by a MKP-1- and PKA-dependent mechanism in rat liver. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360945
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