CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Retargeting of oncolytic adenoviruses by bispecific adapter molecules reduces viral liver load and improves therapy by triggering antigen-specific CD8 T-cell responses
DOI 10.1055/s-0033-1360992
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Kloos, E Gürlevik, N Woller, CI Ureche, MP Manns, R Gerardy-Schahn, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Polysialic acid (PolySia) represents an excellent tumor-selective target for oncolytic adenovirus-based therapies since it is selectively expressed on several malignant tumors. In this study, we used a strategy to retarget oncolytic Adenoviruses (OAV) to PolySia-expressing tumors using the bispecific adapter protein CARsc-pSia consisting of the soluble CAR ectodomain and a PolySia-binding scFv domain. By infection e…
Zitieren
Zitierempfehlung
A Kloos, E Gürlevik, N Woller, CI Ureche, MP Manns, R Gerardy-Schahn, S Kubicka, F Kühnel (2014) Retargeting of oncolytic adenoviruses by bispecific adapter molecules reduces viral liver load and improves therapy by triggering antigen-specific CD8 T-cell responses. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360992
Mit CareLit weiterarbeiten