CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The Serum Reponse Factor (SRF) is involved in the transcriptional upregulation of the functional p53 inhibitor MDM 4 in hepatocellular carcinoma
DOI 10.1055/s-0033-1361003
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Nachweis in CareLit
Autor:innenR Pellegrino, A Thavamani, R Geffers, P Schirmacher, A Nordheim, T Longerich
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
MDM 4 is a p53 binding protein that negatively regulates p53-dependent transcription. MDM 4 was found overexpressed in a variety of human cancers and amplifications of the MDM 4 gene locus were reported most of these tumor entities. We have previously demonstrated that MDM 4 is upregulated in about 50% of human hepatocellular carcinomas (HCC), both at messenger RNA (mRNA) and protein level. Although we identified 1q…
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Zitierempfehlung
R Pellegrino, A Thavamani, R Geffers, P Schirmacher, A Nordheim, T Longerich (2014) The Serum Reponse Factor (SRF) is involved in the transcriptional upregulation of the functional p53 inhibitor MDM 4 in hepatocellular carcinoma. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1361003
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