CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A protective HLA-B*27 restricted epitope contributes to viral control in chronic HCV infection despite presence of viral escape mutations and is characterized by a unique T cell phenotype
DOI 10.1055/s-0033-1361010
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Nachweis in CareLit
Autor:innenB Martin, B Bengsch, K Nitschke, R Thimme, C Neumann-Haefelin
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction and aim: The HLA class I allele B*27 is associated with spontaneous HCV clearance. We have previously linked this protective effect of HLA-B*27 to an immunodominant HLA-B*27 restricted CD8+ T cell epitope located in NS5B. Viral escape within this CD8+ T cell epitope follows a complicated pathway of several mutations, thus, in most HLA-B*27+ subjects, HCV is cleared by the immune response before viral es…
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Zitierempfehlung
B Martin, B Bengsch, K Nitschke, R Thimme, C Neumann-Haefelin (2014) A protective HLA-B*27 restricted epitope contributes to viral control in chronic HCV infection despite presence of viral escape mutations and is characterized by a unique T cell phenotype. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1361010
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