CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Comparison of different inhibitory pathways in hepatitis B virus-specific CD8+ T cell exhaustion
DOI 10.1055/s-0033-1361011
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Autor:innenK Busch, A Hoh, R Thimme
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Objectives: Chronic hepatitis B virus (HBV) infection is characterized by a gradual loss of virus-specific CD8+ T cell functionality. Exhausted HBV-specific CD8+ T cells fail to control viral replication, leading to continued liver inflammation, cirrhosis and development of hepatocellular carcinoma. This deprivation of CD8+ T cell effector functions is mediated by multiple mechanisms, such as inhibitory receptors ex…
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Zitierempfehlung
K Busch, A Hoh, R Thimme (2014) Comparison of different inhibitory pathways in hepatitis B virus-specific CD8+ T cell exhaustion. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1361011
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