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Human non-parenchymal liver cells produce type I and type III interferons in response to poly I:C, thereby mediating an antiviral state against HCV

M Lutterbeck, R Broering, K Kleinehr, A Paul, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · Ausgabe 01/2014

DOI 10.1055/s-0033-1361032

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Autor:innenM Lutterbeck, R Broering, K Kleinehr, A Paul, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: Non-parenchymal liver cells (NPC) play a crucial role in innate immunity and are involved in induction of immune tolerance. Their role in the defense against hepatotrophic viruses such as hepatitis C virus (HCV) is not well understood. Previously, this question has been mostly addressed in murine hepatocytes and NPC. Therefore, aim of the study was to characterize the Toll-like receptor (TLR)-mediated…

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M Lutterbeck, R Broering, K Kleinehr, A Paul, G Gerken, JF Schlaak (2014) Human non-parenchymal liver cells produce type I and type III interferons in response to poly I:C, thereby mediating an antiviral state against HCV. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1361032

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