CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Proliferation of hepatitis B virus infected human hepatocytes in humanized mice treated with the entry inhibitor Myrcludex-B induces strong cccDNA reduction and maintenance of cccDNA-free hepatocytes
DOI 10.1055/s-0033-1361045
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Nachweis in CareLit
Autor:innenL Allweiss, T Volz, K Giersch, J Petersen, AW Lohse, M Lütgehetmann, M Dandri
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
In chronic hepatitis B virus (HBV) infection, the viral genome forms a stable minichromosome, the covalently closed circular DNA (cccDNA), which can persist throughout the hepatocyte lifespan. Immune mediated cell injury and compensatory cell growth, however, appear to favor cccDNA destabilization, leading to the selection of cccDNA-free hepatocytes. Aim of the study was to determine the proliferative capacities of…
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Zitierempfehlung
L Allweiss, T Volz, K Giersch, J Petersen, AW Lohse, M Lütgehetmann, M Dandri (2014) Proliferation of hepatitis B virus infected human hepatocytes in humanized mice treated with the entry inhibitor Myrcludex-B induces strong cccDNA reduction and maintenance of cccDNA-free hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1361045
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