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GFL-dependent TRP channel activation and its impact on airway hyperreactivity in asthma

R Nandigama, A Weske, S Wiegand, W Ummer, C Nassenstein · Pneumologie · Ausgabe 02/2014

DOI 10.1055/s-0033-1363102

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Autor:innenR Nandigama, A Weske, S Wiegand, W Ummer, C Nassenstein
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Glial cell-line derived growth factor (GDNF) and artemin are neurotrophic factors of the GDNF family of ligands. GDNF binds to its co-receptor GDNF family receptor alpha1 (GFRα1) and artemin to GFRα3. Both signal through the receptor tyrosine kinase RET. Previously, we have shown that GFL-receptors and channels of the transient receptor potential (TRP) family, TRPV1 and TRPA1, are co-expressed in lung-labelled jugul…

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R Nandigama, A Weske, S Wiegand, W Ummer, C Nassenstein (2014) GFL-dependent TRP channel activation and its impact on airway hyperreactivity in asthma. Pneumologie (02). https://doi.org/10.1055/s-0033-1363102

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