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Efficient bioactive delivery of aerosolized drugs to pulmonary cells at the air-liquid interface: Validation of the ALICE-CLOUD technology

AG Lenz, T Stoeger, D Cei, M Schmidmeir, N Pfister, G Burgstaller, B Lentner, O Eickelberg, S Meiners, O Schmid · Pneumologie · Ausgabe 02/2014

DOI 10.1055/s-0033-1363120

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Autor:innenAG Lenz, T Stoeger, D Cei, M Schmidmeir, N Pfister, G Burgstaller, B Lentner, O Eickelberg, S Meiners, O Schmid
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: A major bottleneck for testing drugs for inhalation therapy is the lack of realistic and simple to operate in vitro systems. Here we present an easy-to-use in vitro system (ALICE-CLOUD) for efficient delivery of aerosolized aqueous drugs to lung epithelial cells cultured under realistic air-liquid interface (ALI) conditions. Methods: The ALICE-CLOUD utilizes the principles of cloud motion for fast and…

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AG Lenz, T Stoeger, D Cei, M Schmidmeir, N Pfister, G Burgstaller, B Lentner, O Eickelberg, S Meiners, O Schmid (2014) Efficient bioactive delivery of aerosolized drugs to pulmonary cells at the air-liquid interface: Validation of the ALICE-CLOUD technology. Pneumologie (02). https://doi.org/10.1055/s-0033-1363120

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