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Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates Ventilator-induced lung injury in mice

HC Müller-Redetzky, M Felten, M Polikarpova, K Hellwig, S Wienhold, J Naujoks, B Opitz, O Kershaw, AD Gruber, N Suttorp, M Witzenrath · Pneumologie · Ausgabe 02/2014

DOI 10.1055/s-0033-1363127

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Autor:innenHC Müller-Redetzky, M Felten, M Polikarpova, K Hellwig, S Wienhold, J Naujoks, B Opitz, O Kershaw, AD Gruber, N Suttorp, M Witzenrath
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Rationale: Lung protective ventilation in order to minimize ventilator-induced lung injury (VILI) reduced mortality in ARDS. Besides limiting tidal volumes, avoiding high plateau pressures and applying adequate levels of positive end expiratory pressure (PEEP), adjustment of ventilatory pattern aiming at lung protective ventilation is not defined to date. Increasing the inspiratory time and thereby the inspiratory/e…

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HC Müller-Redetzky, M Felten, M Polikarpova, K Hellwig, S Wienhold, J Naujoks, B Opitz, O Kershaw, AD Gruber, N Suttorp, M Witzenrath (2014) Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates Ventilator-induced lung injury in mice. Pneumologie (02). https://doi.org/10.1055/s-0033-1363127

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