A novel mouse model to decode the function of immunoglobulin E in allergy

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Introduction: Human allergy is a debilitating disease in developed countries. Its symptoms range from hay fever attacks, dermatitis, asthma to life threatening anaphylaxis. While decades of research have shown that chronic inflammation driven by B cells and allergen specific immunoglobulin is at the core of the disease, we still lack an in depth understanding of regulatory mechanisms involved. In particular, we stil…

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