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Hypoxia and the hypoxia-regulated transcription factor HIF-1alpha regulate innate immune responses in respiratory epithelial cells

M Polke, PM Lepper, A Kamyschnikow, F Langer, D Monz, R Bals, C Beisswenger · Pneumologie · Ausgabe 02/2014

DOI 10.1055/s-0033-1363133

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Autor:innenM Polke, PM Lepper, A Kamyschnikow, F Langer, D Monz, R Bals, C Beisswenger
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben

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Introduction: Acute and chronic diseases of the respiratory tract, such as pneumonia, cystic fibrosis, and COPD, are associated with mucosal and systemic hypoxia. Bacterial infections contribute to exacerbations in these diseases. Innate immune functions of respiratory epithelial cells are required to control and prevent colonization of the lung with bacterial pathogens. Our aim was to examine whether hypoxia and HI…

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M Polke, PM Lepper, A Kamyschnikow, F Langer, D Monz, R Bals, C Beisswenger (2014) Hypoxia and the hypoxia-regulated transcription factor HIF-1alpha regulate innate immune responses in respiratory epithelial cells. Pneumologie (02). https://doi.org/10.1055/s-0033-1363133

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