CareLit · DOI-Nachweis · Pneumologie
Blockade of Pannexin-1 (PX1) reduces inflammation and colonization in bacterial pneumonia
DOI 10.1055/s-0034-1367899
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Wonnenberg, T Tschernig, M Voss, M Bischoff, C Meier, R Bals, C Beisswenger
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
A recent paper has shown that the activation of inflammasome signaling mediates pathology of acute Pseudomonas aeruginosa pneumonia. The authors suggest the inflammasome as a target to limit the pathological consequences of acute P. aeruginosa lung infection. Pannexin-1 channels mediate activation of caspase-1 and release of IL-1β induced by P2X7 receptor activation. The approved drug probenecid is an inhibitor of p…
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Zitierempfehlung
B Wonnenberg, T Tschernig, M Voss, M Bischoff, C Meier, R Bals, C Beisswenger (2014) Blockade of Pannexin-1 (PX1) reduces inflammation and colonization in bacterial pneumonia. Pneumologie (02). https://doi.org/10.1055/s-0034-1367899
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