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Neutralizing the complement component C5a protects against lung injury and extrapulmonary organ injury in pneumococcal pneumonia induced sepsis

H Müller-Redetzky, U Henke-Kellermann, T Tschernig, S Wienhold, M Polikarpova, K Hellwig, A Vater, C Maasch, S Klussman, MD Menger, N Suttorp, M Witzenrath · Pneumologie · Ausgabe 02/2014

DOI 10.1055/s-0034-1367904

Bibliografische Angaben

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Autor:innenH Müller-Redetzky, U Henke-Kellermann, T Tschernig, S Wienhold, M Polikarpova, K Hellwig, A Vater, C Maasch, S Klussman, MD Menger, N Suttorp, M Witzenrath
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Rationale: Severe community acquired pneumonia (sCAP) and resultant sepsis cause high lethality despite adequate antibiotic treatment. S. pneumoniae is the most prevalent causative pathogen of sCAP. Uncontrolled inflammatory host responses likely contribute to unfavourable outcome by aggravating lung and extrapulmonary organ injury. The complement system is involved in the immune response against infection but also…

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Zitierempfehlung

H Müller-Redetzky, U Henke-Kellermann, T Tschernig, S Wienhold, M Polikarpova, K Hellwig, A Vater, C Maasch, S Klussman, MD Menger, N Suttorp, M Witzenrath (2014) Neutralizing the complement component C5a protects against lung injury and extrapulmonary organ injury in pneumococcal pneumonia induced sepsis. Pneumologie (02). https://doi.org/10.1055/s-0034-1367904

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