CareLit · DOI-Nachweis · Pneumologie
Acquired resistance in NSCLC with EGFR mutation treated with TKI's: Single center experience and treatment outcome
DOI 10.1055/s-0034-1367987
Bibliografische Angaben
Nachweis in CareLit
Autor:innenF Griesinger, V Halbfass, C Hallas, RP Henke, M Falk, A Lüers, M Tiemann
ZeitschriftPneumologie
Ausgabe02/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Acquired resistance in NSCLC with activating EGFR mutations has been defined by Jackman et al. The molecular mechanisms have been studied in small series of patients: in about 50% of cases, T790 M mutation confers acquired resistance, in 25% c-Met amplification. Other as of yet unknown mechanisms might also play a role. Here we present the acquired resistance mechanisms in a cohort of 16 patients (out of…
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Zitierempfehlung
F Griesinger, V Halbfass, C Hallas, RP Henke, M Falk, A Lüers, M Tiemann (2014) Acquired resistance in NSCLC with EGFR mutation treated with TKI's: Single center experience and treatment outcome. Pneumologie (02). https://doi.org/10.1055/s-0034-1367987
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