CareLit · DOI-Nachweis · Klinische Pädiatrie
O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and resistance of Hodgkin's Lymphoma Cells against Dacarbazine
DOI 10.1055/s-0034-1371112
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Nachweis in CareLit
Autor:innenS Kewitz, I Volkmer, C Kramm, MS Staege
ZeitschriftKlinische Pädiatrie
Ausgabe03/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Question: For treatment of Hodgkin's lymphoma, dacarbazine represents an effective chemotherapeutic agent. It is a prodrug that is activated in vivo to an active compound that acts mainly by generation of O6-methylguanine. This methylation can be repaired by the enzyme O6-methylguanine-DNA methyltransferase (MGMT) which transfers the methyl group to its active site and thereby inactivates itself. The MGMT promoter c…
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Zitierempfehlung
S Kewitz, I Volkmer, C Kramm, MS Staege (2014) O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and resistance of Hodgkin's Lymphoma Cells against Dacarbazine. Klinische Pädiatrie (03). https://doi.org/10.1055/s-0034-1371112
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