CareLit · DOI-Nachweis · Klinische Pädiatrie
Epigenetic changes accompany altered hemoglobin regulation in juvenile myelomonocytic leukemia
DOI 10.1055/s-0034-1374825
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Fluhr, A Meier, CF Krombholz, CM Niemeyer, C Flotho
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Elevated fetal hemoglobin (HbF) is a common observation in juvenile myelomonocytic leukemia (JMML) and an adverse prognostic factor. We previously reported that DNA hypermethylation of distinct target genes in JMML is also a negative prognostic factor and correlates with altered HbF expression. This led us to speculate that aberrant DNA methylation may be directly involved in the reexpression of HbF in JMML erythroi…
Zitieren
Zitierempfehlung
S Fluhr, A Meier, CF Krombholz, CM Niemeyer, C Flotho (2014) Epigenetic changes accompany altered hemoglobin regulation in juvenile myelomonocytic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374825
Mit CareLit weiterarbeiten