CareLit · DOI-Nachweis · Klinische Pädiatrie
Rag2null/γcnull mice are suitable for long-term in vivo propagation of juvenile myelomonocytic leukemia
DOI 10.1055/s-0034-1374827
Bibliografische Angaben
Nachweis in CareLit
Autor:innenCF Krombholz, K Aumann, D Bertele, A Meier, CM Niemeyer, C Flotho, M Erlacher
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Resistance to therapy in juvenile myelomonocytic leukemia (JMML) is to a large extent determined by epigenetic modifications. For better insight into epigenetic processes in JMML-initiating cells we established a xenotransplantation model of primary human JMML cells in Rag2null/γcnull mice. Persistent engraftment of cells from three patients with different PTPN11 leukemia mutations was achieved by intrahepatic injec…
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Zitierempfehlung
CF Krombholz, K Aumann, D Bertele, A Meier, CM Niemeyer, C Flotho, M Erlacher (2014) Rag2null/γcnull mice are suitable for long-term in vivo propagation of juvenile myelomonocytic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374827
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