CareLit · DOI-Nachweis · Klinische Pädiatrie
A role for Dual Specificity Phosphatase 6 (DUSP6) in the propagation and self-renewal of Acute Myeloid Leukaemia (AML)
DOI 10.1055/s-0034-1374833
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Nachweis in CareLit
Autor:innenL McKenzie, N Martinez-Soria, C Bonifer, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Chromosomal rearrangements are commonly associated with AML. The translocation t(8;21) is the most common rearrangement, found in 10 – 15% of AML and generates the RUNX1/ETO (AML1/ETO, RUNX1/RUNX1T1) fusion protein. A dynamic equilibrium between RUNX1 and RUNX1/ETO binding is required for maintaining the leukaemic phenotype. In spite of being a transcriptional repressor, RNAi experiments identified many direct RUNX1…
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Zitierempfehlung
L McKenzie, N Martinez-Soria, C Bonifer, O Heidenreich (2014) A role for Dual Specificity Phosphatase 6 (DUSP6) in the propagation and self-renewal of Acute Myeloid Leukaemia (AML). Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374833
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