CareLit · DOI-Nachweis · Klinische Pädiatrie
“In vivo” shRNA screen for the identification of the RUNX1/ETO targets with a relevance in leukaemogenesis
DOI 10.1055/s-0034-1374835
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Martinez-Soria, H Blair, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The t(8;21) translocation results in the expression of the oncogenic fusion protein RUNX1/ETO. This transcription factor affects transcriptional regulation predisposing to leukaemia. To interrogate RUNX1/ETO partner and target genes for their involvement in leukaemic propagation, we performed an shRNA screen. This screen contained shRNAs against up-regulated (PTK2, ANGPT1) as well as down-regulated (CEBP/α) direct a…
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Zitierempfehlung
N Martinez-Soria, H Blair, O Heidenreich (2014) “In vivo” shRNA screen for the identification of the RUNX1/ETO targets with a relevance in leukaemogenesis. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374835
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