CareLit · DOI-Nachweis · Klinische Pädiatrie
Overcoming apoptosis resistance in high risk acute lymphoblastic leukemia by SMAC mimetics in a preclinical all xenograft model
DOI 10.1055/s-0034-1374836
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Schirmer, M Queudeville, L Trentin, SM Eckhoff, LH Meyer, KM Debatin
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
* equal contribution Defects in cell death signaling e.g. overexpression of “Inhibitor of Apoptosis” (IAP) proteins might be one reason for treatment failure of acute leukemia. Therefore, IAP antagonists, so called SMAC mimetics (SMs), provide a promising novel treatment strategy for ALL. We investigated the effects of SMs on 42 primary ALL samples. Intriguingly, 70% of all patient-derived leukemias showed cell deat…
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Zitierempfehlung
M Schirmer, M Queudeville, L Trentin, SM Eckhoff, LH Meyer, KM Debatin (2014) Overcoming apoptosis resistance in high risk acute lymphoblastic leukemia by SMAC mimetics in a preclinical all xenograft model. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374836
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