CareLit · DOI-Nachweis · Klinische Pädiatrie
Transient apoptosis inhibition in donor cells increases efficacy of hematopoietic stem cell transplantation without increasing the risk of leukemogenesis
DOI 10.1055/s-0034-1374838
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Kollek, G Voigt, D Bertele, A Garcia, U Maurer, F Krombholz, V Labi, N Fischer, C Niemeyer, S Geley, A Villunger, M Erlacher
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hematopoietic stem cell transplantation (HSCT) is still associated with several risks. Here, we propose to inhibit apoptosis in donor hematopoietic stem and progenitor cells (HSPC) to increase efficacy of HSCT and to lower the risk of graft failure or delayed engraftment. We have previously shown that the BH3-only proteins, Bim and Bmf play major roles in apoptosis induction of HSPC, and that inhibition of either pr…
Zitieren
Zitierempfehlung
M Kollek, G Voigt, D Bertele, A Garcia, U Maurer, F Krombholz, V Labi, N Fischer, C Niemeyer, S Geley, A Villunger, M Erlacher (2014) Transient apoptosis inhibition in donor cells increases efficacy of hematopoietic stem cell transplantation without increasing the risk of leukemogenesis. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374838
Mit CareLit weiterarbeiten