CareLit · DOI-Nachweis · Klinische Pädiatrie
Timely controlled T-cell receptor expression against a leukemia-associated antigen for the co-transplantation of MHC-mismatched T-cell precursors into hematopoietic stem cell recipients
DOI 10.1055/s-0034-1374840
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Hoseini, M Hapke, J Herbst, N Heinz, B Schiedlmeyer, A Krüger, M Sauer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Adoptive transfer (AT) of TCR-gene modified T cells has been associated with several drawbacks: 1) In vitro stimulation required for TCR-gene transduction can profoundly impact its vivo function after AT; 2) TCR-chain mispairing can cause potentially life threatening autoreactivity; and 3) HLA-matched T cell donors are required. Here, we report the in vitro generation of precursor T-cells, with a phenotype similar t…
Zitieren
Zitierempfehlung
S Hoseini, M Hapke, J Herbst, N Heinz, B Schiedlmeyer, A Krüger, M Sauer (2014) Timely controlled T-cell receptor expression against a leukemia-associated antigen for the co-transplantation of MHC-mismatched T-cell precursors into hematopoietic stem cell recipients. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374840
Mit CareLit weiterarbeiten