CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of leukemia initiating cells in pediatric acute lymphoblastic leukemia
DOI 10.1055/s-0034-1374841
Bibliografische Angaben
Nachweis in CareLit
Autor:innenL Trentin, M Queudeville, SM Eckhoff, N Hasan, KM Debatin, LH Meyer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Conflicting data on the nature of leukemia initiating cells (LICs) in acute lymphoblastic leukemia (ALL) have prompted us to functionally characterize LICs defined by high repopulating activity upon xenotransplantation. We sorted ALL cells according to cell cycle (cc) phases followed by transplantation onto NOD/SCID mice. All sub-fractions led to engraftment. Cells of G0/G1 cc phases led to early leukemia onset in c…
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Zitierempfehlung
L Trentin, M Queudeville, SM Eckhoff, N Hasan, KM Debatin, LH Meyer (2014) Identification of leukemia initiating cells in pediatric acute lymphoblastic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374841
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