CareLit · DOI-Nachweis · Klinische Pädiatrie
Genetic analysis of adamantinomatous craniopharyngioma (ACP)
DOI 10.1055/s-0034-1374842
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Nachweis in CareLit
Autor:innenT Goschzik, HL Müller, T Pietsch
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
From a cohort of 123 ACPs our aim was to gain further information on the molecular genetics and biology of this rare benign tumor entity. DNA was extracted from FFPE-tissue (partly by laser capture microdissection) and CTNNB1 mutational status was analysed by direct sequencing. Even though all ACPs show nuclear ß-catenin accumulation in some tumor cells indicating Wnt pathway activation, only 71% were found mutated…
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Zitierempfehlung
T Goschzik, HL Müller, T Pietsch (2014) Genetic analysis of adamantinomatous craniopharyngioma (ACP). Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374842
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