CareLit · DOI-Nachweis · Klinische Pädiatrie
Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to activation of the NF-kB signalling pathway
DOI 10.1055/s-0034-1374846
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Nachweis in CareLit
Autor:innenT Pietsch, I Wohlers, T Goschzik, V Dreschmann, D Denkhaus, E Dörner, S Rahmann, L Klein-Hitpass
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Supratentorial ependymomas differ from ependymomas of infratentorial or spinal location in respect to their clinical presentation, biology and genetics. We performed RNA sequencing and SNP6.0 profiling in 20 tumor samples. A novel recurrent fusion between C11orf95, a gene with unknown function, and RELA encoding the RelA p65 subunit of NF-kB was identified in 16/20 tumors. This fusion transcript resulted in an N-ter…
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Zitierempfehlung
T Pietsch, I Wohlers, T Goschzik, V Dreschmann, D Denkhaus, E Dörner, S Rahmann, L Klein-Hitpass (2014) Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to activation of the NF-kB signalling pathway. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374846
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