CareLit · DOI-Nachweis · Klinische Pädiatrie
Establishing a model for functional characterisation of somatically mutated genes in neuroblastoma
DOI 10.1055/s-0034-1374848
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Krämer, S Ackermann, F Roels, H Kocak, F Hertwig, Y Kahlert, A Engesser, E Arnz, F Ikram, M Peifer, R Thomas, JH Schulte, M Fischer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
To identify driver mutations in high risk neuroblastoma, whole-exome sequencing of 125 primary high risk neuroblastoma tumours was performed. Overall, a low mutation rate was observed in comparison to adult cancers, and only a few genes were recurrently mutated, indicating a substantial genomic heterogeneity of this tumour entity. In some tumours, however, known driver mutations were identified in bona fide cancer g…
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Zitierempfehlung
A Krämer, S Ackermann, F Roels, H Kocak, F Hertwig, Y Kahlert, A Engesser, E Arnz, F Ikram, M Peifer, R Thomas, JH Schulte, M Fischer (2014) Establishing a model for functional characterisation of somatically mutated genes in neuroblastoma. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374848
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