CareLit · DOI-Nachweis · Klinische Pädiatrie
Synthetic diblock copolymer micelles as vectors for siRNA delivery to knockdown RUNX1/ETO in acute myeloid leukaemia cells
DOI 10.1055/s-0034-1374854
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Coleman, M Omedes-Pujol, C Allen, O Heidenreich, D Fulton
ZeitschriftKlinische Pädiatrie
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Knockdown of RUNX1/ETO using short interfering ribonucleic acids (siRNAs) in vitro has been shown to inhibit acute myeloid leukaemia (AML) cell growth and proliferation. Due to the poor pharmacokinetic properties of siRNA a delivery system is required for therapeutic use in vivo. We propose a polymeric nanoparticle (PNP) system consisting of two diblock copolymers which allow for rapid determination of structure-act…
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Zitierempfehlung
D Coleman, M Omedes-Pujol, C Allen, O Heidenreich, D Fulton (2014) Synthetic diblock copolymer micelles as vectors for siRNA delivery to knockdown RUNX1/ETO in acute myeloid leukaemia cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0034-1374854
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