CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Mice with point mutations in Ffar1 display impaired glucose tolerance
DOI 10.1055/s-0034-1374877
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Autor:innenG Kaiser, F Gerst, S Ullrich, HU Häring, G Przemeck, S Sabrautzki, M Hrabĕ de Angelis
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aim: The fatty acid receptor 1 (FFAR1) is expressed in beta-cells and mediates fatty acid-dependent augmentation of GSIS. This feature led to the generation of specific FFAR1-agonists for the treatment of hyperglycaemia. Intriguingly, Ffar1 (-/-) mice were protected against liver steatosis, suggesting that antagonists of Ffar1 could have beneficial effects on metabolism. These opposing observations were made in gene…
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Zitierempfehlung
G Kaiser, F Gerst, S Ullrich, HU Häring, G Przemeck, S Sabrautzki, M Hrabĕ de Angelis (2014) Mice with point mutations in Ffar1 display impaired glucose tolerance. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1374877
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