CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
PKCdelta-dependent phosphorylation of 14 – 3-3zeta delays the nuclear export of FOXO1 in beta-cells
DOI 10.1055/s-0034-1374924
Bibliografische Angaben
Nachweis in CareLit
Autor:innenF Gerst, G Kaiser, M Panse, A Pujol, F Bosch, HU Häring, S Ullrich
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aim: Fatty acid-induced beta-cell death accounts for insulin deficiency during the onset of obesity-linked diabetes. Previous observations suggest that inhibition of PKCdelta impairs nuclear accumulation of FOXO1 and protects against palmitate-induced apoptosis. The present study aims at examining the mechanism of PKCdelta-dependent nucleo-cytoplasmic shuttling of FOXO1 and its relevance for fatty aci…
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Zitierempfehlung
F Gerst, G Kaiser, M Panse, A Pujol, F Bosch, HU Häring, S Ullrich (2014) PKCdelta-dependent phosphorylation of 14 – 3-3zeta delays the nuclear export of FOXO1 in beta-cells. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1374924
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