CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The anti-inflammatory protein NUPR1 protects pancreatic islets from diabetogenic lipotoxic injury ex vivo
DOI 10.1055/s-0034-1374927
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Mihic-Necic, AE Mehana, C Liu, L Parsons, J Baumann, N Perakakis, K Laubner, J Seufert, G Päth
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aim: According to the so-called “nutrition overflow hypothesis”, type 2 diabetes results from nutrition-induced local tissue inflammation leading to insulin resistance, insulin secretory dysfunction and finally pancreatic β-cell loss. Free fatty acids (FFA) acting through toll-like receptors are key mediators of this lipotoxic inflammatory response. We previously demonstrated that the intracellular pr…
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Zitierempfehlung
B Mihic-Necic, AE Mehana, C Liu, L Parsons, J Baumann, N Perakakis, K Laubner, J Seufert, G Päth (2014) The anti-inflammatory protein NUPR1 protects pancreatic islets from diabetogenic lipotoxic injury ex vivo. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1374927
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