CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The anti-inflammatory protein NUPR1 (p8) is a novel intracellular mediator of pancreatic β-cell protection during diabetogenic stress in vitro and in vivo
DOI 10.1055/s-0034-1374962
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Nachweis in CareLit
Autor:innenAE Mehana, I Pilz, B Dufner, C Jäger, S Sojka, J Baumann, M Alt, C Liu, B Mihic-Necic, L Parsons, N Perakakis, K Laubner, G Päth, J Seufert
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The intracellular protein NUPR1 (alias p8) reduces tissue damage during acute pancreatitis, and its expression is enriched in pancreatic islets. Therefore, we hypothesized that NUPR1 may exert protective mechanisms in the endocrine pancreas under inflammatory diabetogenic stress. This was investigated in transgenic mice with β-cell-specific NUPR1 overexpression (Tg). Methods: Mice were fed a high fat d…
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Zitierempfehlung
AE Mehana, I Pilz, B Dufner, C Jäger, S Sojka, J Baumann, M Alt, C Liu, B Mihic-Necic, L Parsons, N Perakakis, K Laubner, G Päth, J Seufert (2014) The anti-inflammatory protein NUPR1 (p8) is a novel intracellular mediator of pancreatic β-cell protection during diabetogenic stress in vitro and in vivo. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1374962
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