CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Regulation of thioredoxin interacting protein by FFA1 ligands under hyperglycemic conditions
DOI 10.1055/s-0034-1374963
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Autor:innenM Panse, G Kaiser, F Gerst, HU Häring, S Ullrich
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aim: Multiple observations suggest that glucose-dependent stimulation of thioredoxin interacting protein (TxNIP) expression contributes to glucotoxicity. TxNIP inhibits thioredoxin thereby increasing the mitochondrial oxidative stress. TxNIP is transcriptionally activated by ChREBP, while FOXO1 antagonizes ChREBP binding to the TxNIP promoter. Glucose increases nuclear accumulation of ChREBP. Palmitic…
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Zitierempfehlung
M Panse, G Kaiser, F Gerst, HU Häring, S Ullrich (2014) Regulation of thioredoxin interacting protein by FFA1 ligands under hyperglycemic conditions. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1374963
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