CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
L-serine supplementation suppresses the formaiton of neurotoxic deoxysphingolipids and improves neuropathy in a type 1 diabetic rat model
DOI 10.1055/s-0034-1375013
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Nachweis in CareLit
Autor:innenT Hornemann, A Othman, A von Eckardstein, C Porretta-Serapiglia, G Lauria, R Bianchi
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
1-Deoxyceramides (deoxyCer) are atypical ceramides which are formed by the enzyme serine-palmitoyltransferase (SPT) due to a promiscuous use of L-alanine over its canonical substrate L-serine. DeoxyCer are neurotoxic and induce neurite retraction in cultured primary neurons. Pathologically increased deoxyCer levels cause HSAN1, an inherited axonal neuropathy which is associated with several missense mutations in SPT…
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Zitierempfehlung
T Hornemann, A Othman, A von Eckardstein, C Porretta-Serapiglia, G Lauria, R Bianchi (2014) L-serine supplementation suppresses the formaiton of neurotoxic deoxysphingolipids and improves neuropathy in a type 1 diabetic rat model. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1375013
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