CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Activation of the Nlrp3 inflammasome via mitochondrial ROS in glomerular cells aggravates experimental diabetic nephropathy
DOI 10.1055/s-0034-1375018
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Shahzad, F Bock, H Wang, S Kopf, C Wacker, S Kohli, J Wolter, S Ranjan, K Reymann, S Stoyanov, HJ Groene, T Madhusudhan, P Nawroth, B Isermann
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Sterile inflammation and activation of the NLRP3-Inflammosome have been implicated in diabetes. Mitochondrial ROS are a known trigger of the inflammasome. Whether inflammosome activation is causally involved in the pathogenesis of diabetic nephropathy and whether resident or bone marrow derived inflammatory cells are involved remains unkown. Methods: Murine models of type-2 and type-1 diabetes and diab…
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Zitierempfehlung
K Shahzad, F Bock, H Wang, S Kopf, C Wacker, S Kohli, J Wolter, S Ranjan, K Reymann, S Stoyanov, HJ Groene, T Madhusudhan, P Nawroth, B Isermann (2014) Activation of the Nlrp3 inflammasome via mitochondrial ROS in glomerular cells aggravates experimental diabetic nephropathy. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1375018
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