CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Effects of linagliptin on glucose-induced neuronal damage on Caenorhabditis elegans
DOI 10.1055/s-0034-1375105
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Autor:innenK Wongchai, A Schlotterer, J Lin, M Morcos, T Klein, HP Hammes
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: C. elegans lacks a vascular system and is therefore an ideal model system to investigate the mechanisms of glucose-mediated damage to neurons. Experimental hyperglycaemia causes neuronal dysfunction in C. elegans and reduces lifespan by overproduction of ROS and MG-derived AGEs. A key regulator for longevity and stress response is DAF-16, which up-regulates MnSOD, an enzyme detoxifying ROS. Here we use…
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Zitierempfehlung
K Wongchai, A Schlotterer, J Lin, M Morcos, T Klein, HP Hammes (2014) Effects of linagliptin on glucose-induced neuronal damage on Caenorhabditis elegans. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0034-1375105
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