CareLit · DOI-Nachweis · Pneumologie
Deregulation of ORMDL3 expression induces stress responses and modulates repair pathways
DOI 10.1055/s-0034-1376771
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Autor:innenK Kallsen, C Fink, A Bhandari, M Kabesch, H Heine, T Roeder
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The asthma-susceptibility gene ORMDL3 is an ER transmembrane protein previously associated with sphingolipid metabolism, the unfolded protein response, Ca2+ homeostasis, T-cell activation, and antiviral responses. However, the functional relevance of ORMDL3 in asthma pathogenesis remains elusive. Using the fruit fly Drosophila melanogaster as a model, we mimicked the situation found in patients at risk for asthma by…
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Zitierempfehlung
K Kallsen, C Fink, A Bhandari, M Kabesch, H Heine, T Roeder (2014) Deregulation of ORMDL3 expression induces stress responses and modulates repair pathways. Pneumologie (06). https://doi.org/10.1055/s-0034-1376771
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