CareLit · DOI-Nachweis · Pneumologie
Aberrant expression and activity of histone deacetylases (HDAC) in lungs of patients with sporadic idiopathic pulmonary fibrosis (IPF)
DOI 10.1055/s-0034-1376797
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Nachweis in CareLit
Autor:innenM Korfei, S Skwarna, I Henneke, O Klymenko, G Dahlem, S Ziegler, D von der Beck, W Klepetko, L Fink, W Seeger, O Krämer, A Guenther
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Histone deacetylases (HDACs) are enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on histones, resulting in epigenetic repression of gene transcription. HDACs can also catalyze deacetylation of many non-histone proteins, such as the tumor suppressor p53, resulting in inhibition of its pro-apoptotic activity. HDACs thus pivotally control gene expression and cellular signaling. Due…
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Zitierempfehlung
M Korfei, S Skwarna, I Henneke, O Klymenko, G Dahlem, S Ziegler, D von der Beck, W Klepetko, L Fink, W Seeger, O Krämer, A Guenther (2014) Aberrant expression and activity of histone deacetylases (HDAC) in lungs of patients with sporadic idiopathic pulmonary fibrosis (IPF). Pneumologie (06). https://doi.org/10.1055/s-0034-1376797
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