CareLit · DOI-Nachweis · Pneumologie
Development of a new mouse model to assess the therapeutic efficacy of GRP78 for prevention and resolution of ER stress in vivo
DOI 10.1055/s-0034-1376805
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Autor:innenI Henneke, C Ruppert, A Günther, M Korfei
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
It is known, that ER-stress plays a role in several, very different diseases like artherosclerosis, dilated cardiomyopathy or neurodegenerative diseases. Maladaptive ER-stress was also indicated to play a prominent role in IPF and seems to represent a key trigger in the pathogenesis of this disease. As 78kDa glucose-regulated protein/immunoglobulin-binding protein (Grp78/Bip) is the key chaperone of the ER, and as i…
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Zitierempfehlung
I Henneke, C Ruppert, A Günther, M Korfei (2014) Development of a new mouse model to assess the therapeutic efficacy of GRP78 for prevention and resolution of ER stress in vivo. Pneumologie (06). https://doi.org/10.1055/s-0034-1376805
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