CareLit · DOI-Nachweis · Pneumologie
Biological role of the proapoptotic transcription factor C/EBP homologous protein (CHOP) in Idiopathic Pulmonary Fibrosis (IPF)
DOI 10.1055/s-0034-1376806
Bibliografische Angaben
Nachweis in CareLit
Autor:innenO Klymenko, I Henneke, C Ruppert, W Seeger, A Guenther, M Korfei
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We have recently identified severe and pro-apoptotic Endoplasmic Reticulum (ER) stress as major pathomechanism for alveolar epithelial cell (AEC) injury in Idiopathic Pulmonary Fibrosis (IPF). In line with this, the pro-apoptotic transcription factor CHOP, which functions as a crucial mediator of ER stress-induced apoptosis, was strongly induced in AECII from patients with IPF. We therefore aimed to fully disclose t…
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Zitierempfehlung
O Klymenko, I Henneke, C Ruppert, W Seeger, A Guenther, M Korfei (2014) Biological role of the proapoptotic transcription factor C/EBP homologous protein (CHOP) in Idiopathic Pulmonary Fibrosis (IPF). Pneumologie (06). https://doi.org/10.1055/s-0034-1376806
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