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Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis

D Lutz, A Gazdhar, E Lopez-Rodriguez, P Mahavadi, A Günther, W Klepetko, JH Bates, B Smith, T Geiser, M Ochs, L Knudsen · Pneumologie · Ausgabe 06/2014

DOI 10.1055/s-0034-1376809

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Autor:innenD Lutz, A Gazdhar, E Lopez-Rodriguez, P Mahavadi, A Günther, W Klepetko, JH Bates, B Smith, T Geiser, M Ochs, L Knudsen
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Idiopathic pulmonary fibrosis (IPF) and bleomycin-induced pulmonary fibrosis are associated with surfactant system dysfunction, alveolar collapse, and collapse induration (irreversible closure). These events play critical but undefined roles in the loss of lung function and disease progression. To quantify how surfactant inactivation leads to lung injury and fibrosis we employed design-based stereology and invasive…

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Zitierempfehlung

D Lutz, A Gazdhar, E Lopez-Rodriguez, P Mahavadi, A Günther, W Klepetko, JH Bates, B Smith, T Geiser, M Ochs, L Knudsen (2014) Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis. Pneumologie (06). https://doi.org/10.1055/s-0034-1376809

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