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Arachidonic acid/cytochrome p450-derived mediators decrease hypoxic pulmonary vasoconstriction in isolated, ventilated and perfused mouse lungs

A Erb, DM Peters, RT Schermuly, M Heipel, J Bier, K Quanz, W Seeger, F Grimminger, N Weißmann, L Kiss · Pneumologie · Ausgabe 06/2014

DOI 10.1055/s-0034-1376816

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Autor:innenA Erb, DM Peters, RT Schermuly, M Heipel, J Bier, K Quanz, W Seeger, F Grimminger, N Weißmann, L Kiss
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism that adapts perfusion to ventilation to optimize gas exchange by redistributing the blood flow to well-ventilated areas, thereby improving alveolar oxygenation. Disturbances in HPV can lead to life-threatening hypoxemia. Intrinsic and modulatory pathways of HPV are not fully elucidated. Arachidonic acid-derived mediators a…

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A Erb, DM Peters, RT Schermuly, M Heipel, J Bier, K Quanz, W Seeger, F Grimminger, N Weißmann, L Kiss (2014) Arachidonic acid/cytochrome p450-derived mediators decrease hypoxic pulmonary vasoconstriction in isolated, ventilated and perfused mouse lungs. Pneumologie (06). https://doi.org/10.1055/s-0034-1376816

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