CareLit · DOI-Nachweis · Pneumologie
Congenital Pulmonary Alveolar Proteinosis iPS-derived hematopoietic progenitor cells (HPCs) reveal functional defects upon GM-CSF administration
DOI 10.1055/s-0034-1376847
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Mucci, N Lachmann, C Happle, M Ackermann, S Glage, G Hansen, T Moritz
ZeitschriftPneumologie
Ausgabe06/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hereditary Pulmonary Alveolar Proteinosis (herPAP), caused by a mutation in the GM-CSF receptor β-chain (Csf2rb), is an extremely rare lung disease resulting from the inability of alveolar macrophages to clear the alveolar spaces from surfactant phospholipids. Since current treatment options are extremely limited, we here investigate the suitability of a gene therapy approach based on hematopoietic cells derived fro…
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Zitierempfehlung
A Mucci, N Lachmann, C Happle, M Ackermann, S Glage, G Hansen, T Moritz (2014) Congenital Pulmonary Alveolar Proteinosis iPS-derived hematopoietic progenitor cells (HPCs) reveal functional defects upon GM-CSF administration. Pneumologie (06). https://doi.org/10.1055/s-0034-1376847
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