CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Cathepsin B and D drive the fibrogenic potential of pancreatic stellate cells and modulate the stromal compartment in pancreatic ductal adenocarcinoma (PDAC)
DOI 10.1055/s-0034-1386068
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Nachweis in CareLit
Autor:innenUM Mahajan, T Schwaiger, FU Weiss, M Löhr, W Halangk, MM Lerch, J Mayerle
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aim: Remodelled extracellular matrix (ECM) has been implicated in the resistance of cancer cells to chemotherapy. Stromal-cell-derived proteases, e.g. cathepsins, are involved in tumorigenesis and tissue invasion but their role in regulating pancreatic stellate cells (PSCs) and thus ECM-formation is unknown. We studied whether cathepsin B and D, lysosomal proteases both highly expressed in pancreatic cancer, contrib…
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Zitierempfehlung
UM Mahajan, T Schwaiger, FU Weiss, M Löhr, W Halangk, MM Lerch, J Mayerle (2014) Cathepsin B and D drive the fibrogenic potential of pancreatic stellate cells and modulate the stromal compartment in pancreatic ductal adenocarcinoma (PDAC). Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0034-1386068
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