CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Loss of ATM accelerates KrasG12D – induced pancreatic cancer formation
DOI 10.1055/s-0034-1386077
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Russell, L Perkhofer, Q Lin, M Zenke, J Lennerz, T Seufferlein, M Wagner, A Kleger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Onset and progression of pancreatic ductal adenocarcinoma (PDAC) is associated with the accumulation of certain oncogenic mutations and more recently, genome-wide exome sequencing studies have identified ATM mutations in independent PDAC cohorts. However, the role of ATM is in PDAC initiation and progression is unclear. Here we report that conditional deletion of ATM in a mouse model of PDAC enhanced pancreatic canc…
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Zitierempfehlung
R Russell, L Perkhofer, Q Lin, M Zenke, J Lennerz, T Seufferlein, M Wagner, A Kleger (2014) Loss of ATM accelerates KrasG12D – induced pancreatic cancer formation. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0034-1386077
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