CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepadnaviral replication in HBV-transgenic mice lacking the surface antigen (HBsAg) is controlled by toll-like receptor 3-induced immune responses
DOI 10.1055/s-0034-1386084
Bibliografische Angaben
Nachweis in CareLit
Autor:innenCI Real, R Broering, M Hossbach, J Deckert, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, S Driftmann, T Kemper, HP Vornlocher, R Schirmbeck, M Lu, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: It is likely that HBV surface antigen (HBsAg) impairs toll-like receptor (TLR) signaling leading to an attenuation of innate and adaptive immune responses. Here, we aimed to analyze TLR3 signaling in HBV transgenic mice lacking the HBs antigen (1.4 tgHBV-s-mut). Methods: HBxAg-targeting siRNAs or ligand for TLR3 (poly I:C) were injected intravenously into 1.4 tgHBV-s-mut mice and HBV negative li…
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Zitierempfehlung
CI Real, R Broering, M Hossbach, J Deckert, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, S Driftmann, T Kemper, HP Vornlocher, R Schirmbeck, M Lu, G Gerken, JF Schlaak (2014) Hepadnaviral replication in HBV-transgenic mice lacking the surface antigen (HBsAg) is controlled by toll-like receptor 3-induced immune responses. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0034-1386084
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